Protein Modification Reagents
eMolecules 1309451-06-6 | Benzyl-PEG2-CH2CO2tBu | Broadpharm | MFCD28015768 | 266.337 | C15H22O4 | 98.000 | CC(C)(C)OC(=O)COCCOCc1ccccc1 | 1g | 247403047
Benzyl-PEG2-CH2CO2tBu | Broadpharm | 1309451-06-6 | MFCD28015768 | 266.337 | C15H22O4 | 98.000 | CC(C)(C)OC(=O)COCCOCc1ccccc1 | 1g | 247403047
eMolecules 9004-74-4 | m-PEG24-alcohol | Broadpharm | MFCD27977524 | 1089.314 | C49H100O25 | 98.000 | COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO | 1g | 229582254
m-PEG24-alcohol | Broadpharm | 9004-74-4 | MFCD27977524 | 1089.314 | C49H100O25 | 98.000 | COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO | 1g | 229582254
eMolecules 437655-96-4 | Fmoc-NH-PEG6-CH2COOH | Broadpharm | MFCD26142983 | 561.628 | C29H39NO10 | 98.000 | OC(=O)COCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 1g | 340377165
Fmoc-NH-PEG6-CH2COOH | Broadpharm | 437655-96-4 | MFCD26142983 | 561.628 | C29H39NO10 | 98.000 | OC(=O)COCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 1g | 340377165
Medchemexpress LLC Tos-PEG5-CH2COOtBu | 1949793-62-7 | MFCD30828689 | ≥95% | C23H38O10S | 100 MG
Tos-PEG5-CH2COOtBu is a PEG linker that contains a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media, and the t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group serves as an excellent leaving group for nucleophilic substitution reactions. This compound is a PEG-based PROTAC linker used in the synthesis of PROTACs.
- Contains a t-butyl ester and a tosyl group.
- Hydrophilic PEG spacer enhances solubility in aqueous media.
- T-butyl protected carboxyl group can be deprotected under acidic conditions.
- Tosyl group serves as a leaving group for nucleophilic substitution reactions.
- Used as a PEG-based PROTAC linker in PROTAC synthesis.
eMolecules 2279944-66-8 | N,N-diethanol amine-PEG4-tert-butyl ester | Broadpharm409.520 | C19H39NO8 | 0.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCN(CCO)CCO | 1g | 550804567
N,N-diethanol amine-PEG4-tert-butyl ester | Broadpharm | 2279944-66-8409.520 | C19H39NO8 | 0.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCN(CCO)CCO | 1g | 550804567
Medchemexpress LLC M-PEG-mal (MW 2000) | 97.27% | 100 MG
M-PEG-mal (MW 2000) is a PEG-based PROTAC linker designed for the synthesis of PROTACs. PROTACs are innovative molecules that harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins, utilizing two different ligands connected by a linker: one targeting an E3 ubiquitin ligase and the other for the protein of interest.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC NH-bis-PEG4 | 63721-14-2 | 98.0% | C16H35NO8 | 250 MG
NH-bis-PEG4 is a PEG-based PROTAC linker. It is primarily used in the synthesis of PROTACs.
- Store in pure form at -20°C for up to 3 years or 4°C for up to 2 years.
- When in solvent, store at -80°C for up to 6 months or -20°C for up to 1 month.
![eMolecules Amino-Tri-(Azide-PEG10-ethoxymethyl)-methane HCl Salt | Broadpharm |1863.164 | C79H155N13O36 | 90.000 | NC(COCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])(COCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])COCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 500mg | 603...](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502183675.JPG-250.jpg)
eMolecules Amino-Tri-(Azide-PEG10-ethoxymethyl)-methane HCl Salt | Broadpharm |1863.164 | C79H155N13O36 | 90.000 | NC(COCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])(COCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])COCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 500mg | 603...
Amino-Tri-(Azide-PEG10-ethoxymethyl)-methane HCl Salt | Broadpharm |1863.164 | C79H155N13O36 | 90.000 | NC(COCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])(COCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])COCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 500mg | 603111845
Medchemexpress LLC PEG4-aminooxy-MMAF | 1415246-35-3 | MFCD32201151 | 99.8% | 923.19 | C47H82N6O12 | 100 MG
PEG4-aminooxy-MMAF is a drug-linker conjugate for antibody-drug conjugate (ADC) research that combines the antitubulin payload MMAF with a non-cleavable PEG4 aminooxy linker. It is supplied as a solid for formulation and conjugation studies, with recommended storage at -20°C and documented solubility and in vivo formulation methods.
- Drug-linker conjugate for ADC research.
- Contains MMAF payload linked via a non-cleavable PEG4 aminooxy linker.
- Molecular weight 923.19; formula C47H82N6O12.
- CAS number 1415246-35-3.
- Soluble in DMSO at 100 mg/mL; in vivo formulations documented.
- Store at -20°C and protect from light; prepare fresh solutions.
Medchemexpress LLC Mal-PEG2-oxyamine TFA | 00-00-0 | MFCD00209801 | 96.5% | C12H17F3N2O7 | 10MG
Mal-PEG2-oxyamine TFA is a PEG-based bifunctional linker supplied as the trifluoroacetic acid (TFA) salt for use in PROTAC synthesis and other bioconjugation applications. It combines a maleimide reactive group with an oxyamine functional handle, and a short PEG2 spacer to enhance solubility and flexibility.
- Bifunctional linker enabling thiol and carbonyl conjugation.
- Maleimide permits rapid, thiol-selective coupling under mild conditions.
- Oxyamine enables chemoselective oxime ligation to aldehydes and ketones.
- PEG2 spacer increases aqueous solubility and reduces steric hindrance.
- Provided as TFA salt to improve stability and handling.
- High purity suitable for research and synthetic workflows.
Medchemexpress LLC DBCO-PEG4-Biotin | 1255942-07-4 | MFCD22572661 | 99.4% | C39H51N5O8S | 10MG
DBCO-PEG4-Biotin is a dibenzocyclooctyne-linked biotin reagent with a PEG4 spacer designed for copper-free click biotinylation of azide-labeled biomolecules. It enables rapid strain-promoted azide-alkyne cycloaddition to form a stable triazole linkage and introduces a biotin handle for affinity capture or detection in labeling and pull-down applications.
- Enables copper-free strain-promoted azide-alkyne cycloaddition (SPAAC) with azide-labeled substrates.
- Introduces a biotin affinity tag for streptavidin-based capture or detection.
- Peg4 spacer improves solubility and reduces steric hindrance during conjugation.
- High purity suitable for sensitive bioconjugation workflows.
- Offered as solid and as a DMSO solution for flexible experimental use.
- Stable when stored sealed and away from moisture under recommended conditions.
Medchemexpress LLC Propargyl-PEG4-NHS ester | 1428629-70-2 | 97.0% | 357.36 g·mol⁻¹ | C16H23NO8 | 100 MG
Propargyl-PEG4-NHS ester is a PEG4 linker with a terminal propargyl (alkyne) group and an N-hydroxysuccinimide (NHS) ester, designed for bioconjugation via amine coupling and click chemistry.
- Noncleavable four-unit PEG linker for spacer and solubility
- Terminal propargyl group enables copper-catalyzed azide-alkyne cycloaddition
- NHS ester provides rapid and efficient coupling to primary amines
- High purity suitable for research applications
- Molecular weight approximately 357.36 g·mol⁻¹
- Available in small research-scale package sizes
Medchemexpress LLC Mal-PEG36-NHS ester | 00-00-0 | 95.0% | C86H159N3O43 | 10MG
Mal-PEG36-NHS ester is a polyethylene glycol (PEG)-based bifunctional linker bearing a maleimide and an N-hydroxysuccinimide (NHS) activated ester. Supplied as a research-use solid, it facilitates thiol and amine conjugation for PROTAC assembly and other bioconjugation chemistries.
- Enables thiol coupling via maleimide and amine coupling via NHS ester.
- PEG36 spacer provides hydrophilicity and flexible linker length.
- High molecular weight (≈1,923 Da) for extended linker reach.
- Purity approximately 95.0% as provided by manufacturer.
- Soluble in DMSO at ~62.5 mg/mL; documented in vivo formulations exist.
- Recommended storage: -20°C for solid; low-temperature storage for solutions to preserve stability.
- Intended for research use only; not for clinical applications.
Medchemexpress LLC Amino-PEG6-amido-bis-PEG5-N3 | 1147.31 | C48H94N10O21 | 25 MG
A cleavable, PEG-based linker containing an azide functional group and a terminal amino group for bioconjugation. Designed as an 11-unit PEG spacer, it provides hydrophilicity and reactive handles for click chemistry and antibody-drug conjugate synthesis.
- Cleavable 11-unit PEG linker providing hydrophilic spacer.
- Contains an azide group for copper-catalyzed and strain-promoted click reactions.
- Terminal amino group enables further conjugation chemistry.
- Suitable for antibody-drug conjugate and bioconjugation applications.
- Available in small lab pack sizes for research use.